This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 956146.

Werner Weitschies

Professor of Biopharmaceutics, University of Greifswald

(Co-)lead of WP1, (co-)supervisor of ESRs 1, 2 and 6.

Prof. Werner Weitschies is Professor of Biopharmaceutics at the University of Greifswald, Germany. He studied Pharmacy at the Free University of Berlin (1983-1987) and received his Ph.D. in Pharmaceutical Technology in 1990. From 1990 to 1995 he worked as a scientist in the research laboratories of Schering AG in Berlin in the field of injectable microparticulate contrast agents for ultrasound. From 1996 to 1998 he was head of a research department in the field of medical applications of magnetic nanoparticles at the Institute for Diagnostic Research of the Free University of Berlin. In 1998 he was appointed Professor of Pharmaceutical Technology at the Institute of Pharmacy in Greifswald, Germany. His main research areas are the investigation of the interplay between physiology and drug delivery systems with focus on the gastrointestinal tract, and the development of nanoparticle based techniques for molecular imaging and physical therapy. Werner Weitschies is author or co-author of more than 250 scientific articles and 31 patents.

Publications

  • Brodkorb, A., Egger, L., Alminger, M., Alvito, P., Assunção, R., Balance, S., Bohn, T., Bourlieu-Lacanal, C., Boutrou, R., Carrière, F., Clemente, A., Corredig, M., Dupont, D., Dufour, C., Edwards, C., Golding, M., Karakaya, S., Kirkhus, B., Le Feunteun, S., Lesmes, U., Macierzanka, A., Mackie, A.R., Martins, C., Marze, S., McClements, D.J., Ménard, O., Minekus, M., Portmann, R., Santos, C.N., Souchon, I., Singh, R.P., Vegarud, G.E., Wickham, M.S.J., Weitschies, W. and Recio, I. (2019) INFOGEST static in vitro simulation of gastrointestinal food digestion. Nature Protocols, 14, pp. 991-1014. DOI: 10.1038/s41596-018-0119-1
  • Sager, M., Schick, P., Mischek, M., Schulze, C., Hasan, M., Kromrey, M.L., Benameur, H., Wendler, M., Tzvetkov, M.V., Weitschies, W. and Koziolek, M. (2019) Comparison of In Vitro and In Vivo Results Using the GastroDuo and the Salivary Tracer Technique: Immediate Release Dosage Forms under Fasting Conditions. Pharmaceutics, 11, pp. E659. DOI: 10.3390/pharmaceutics11120659
  • Sager, M., Grimm, P., Jedamzik, S., Merdivan, M.L., Kromrey, M., Hasan, M., Koziolek, M., Tzvetkov, V. and Weitschies, W. (2019) Combined application of MRI and the salivary tracer technique to determine the in vivo disintegration time of immediate release formulation administered to healthy, fasted subjects. Molecular Pharmacology, 16, pp. 1782-1786. DOI: 10.1021/acs.molpharmaceut.8b01320
  • Sager, M., Jedamzik, P., Merdivan, S., Grimm, M., Schneider, F., Kromrey, M.L., Hasan, M., Oswald, S., Kühn, J., Koziolek, M. and Weitschies, W. (2018) Low dose caffeine as a salivary tracer for the determination of gastric water emptying in fed and fasted state: A MRI validation study. European Journal of Pharmaceutics and Biopharmaceutics, 127, pp. 443-452. DOI: 10.1016/j.ejpb.2018.03.011
  • Grimm, M., Scholz, E., Koziolek, M., Kühn, J.P. and Weitschies, W. (2017) Gastric Water Emptying under Fed State Clinical Trial Conditions Is as Fast as under Fasted Conditions, Molecular Pharmacology, 14, pp. 4262-4271. DOI: 10.1021/acs.molpharmaceut.7b00623
  • Koziolek, M., Grimm, M., Schneider, F., Jedamzik, P., Sager, M., Kühn, J.P., Siegmund, W. and Weitschies, W. (2016) Navigating the human gastrointestinal tract for oral drug delivery: Uncharted waters and new frontiers, Advanced Drug Delivery Reviews, 101, pp. 75-88. DOI: 10.1016/j.addr.2016.03.009