Open PhD position – ESR 11
Development of open access PBB/PBPK models to predict oral drug absorption in Geriatric Patients and Older People
Planned starting date: 01 August 2021
Host Institution: Bayer AG, Germany (J.-F. Schlender)
PhD Awarding Institution: Katholieke Universiteit Leuven, Belgium
Project Description
Inform an open-source PBB/PBPK database on the basis of in vitro and in vivo data, setting a distinction between age- and/or disease-related impact on drug absorption. Generate evidence for PBB/PBPK modelling and simulation towards older people by defining distinctive case examples to qualify the approach for the intended use.
Expected Results: Mechanistically inform and holistically understand oral absorption changes with ageing and concomitant disease progression by integrating data generated by AGePOP ESRs-1-9 into a whole-body PBB/PBPK model. The project outcome will be perpetuated in an open-source PBPK software facilitating further research beyond the project context.
Planned Secondment
- Katholieke Universiteit Leuven, Belgium (P. Augustijns)
Background
Essential Background
Master’s degree (or equivalent graduation) in relevant area (e.g. pharmacy/pharmaceutical sciences, natural sciences, medicine, engineering, and/or mathematics).
Desirable Background
First insights into programming language (e.g. R, Matlab) are beneficial but not a must. Experience with mechanistic modelling and parameter estimation in ODE systems would be an advantage.