Open PhD position – ESR 10
Application of PBB/PBPK software tools to predict oral drug absorption in older people and geriatric patients and development of an absorption risk calculator to assess the probability of adverse effects in older people due to altered pharmacokinetics.
Planned starting date: 01 August 2021
Host Institution: Merck Healthcare KGaA, Germany (S. Hansmann, A. Lehmann)
PhD Awarding Institution: National and Kapodistrian University of Athens, Greece
Project Description
Evaluation of the predictability of Physiologically based Pharmacokinetic (PBPK) models in context of absorption in older people and geriatric patients. The candidate will utilize data from ESR 1-9 for improving the predictions of absorption-related processes in the advanced age population and will implement an absorption risk calculator to identify the probability of adverse events to happen due to altered absorption/pharmacokinetics.
Expected Results: Use and improve PBPK models for evaluating the performance of orally administered drugs to older people and geriatric patients and propose an absorption risk calculator.
Planned Secondment
- National and Kapodistrian University of Athens, Greece (C. Reppas)
Background
Essential Background
Applicants should preferably have a Master´s degree in a project-related field (e.g. Pharmacy, Pharmaceutical Sciences, Drug Delivery, Industrial Pharmacy).
Desirable Background
First insights into programming language (e.g. R) are beneficial but not a must. German as additional language skill is beneficial but not a must.
Local Requirements
The candidate should be able to work in a diverse project team. A curious and innovative mindset is a prerequisite for the project as well as the ability to communicate results effectively and clearly to an interested scientific community.